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Lupus Research

Lupus is an inflammatory disease that affects areas of the body, such as the skin, joints, and organs. The brain, heart, kidneys, and lungs are just a few organs the disease can affect. Lupus is a chronic disease, so there is no cure. However, recent advances in treatment have made a living with this condition easier.

Lupus primarily affects females going through puberty. 20 percent of lupus patients are children or teenagers. Symptoms of lupus vary from patient to patient. You can see a few symptoms below.

  • Headaches
  • Fatigue
  • Fever
  • Hair loss
  • Weight loss
  • Swelling in the feet, legs, hand, and joints
  • Chest pains when breathing deeply
  • Lack of blood circulation in the hands
  • Anemia
  • Mouth or nose sores

Treating Lupus

Lupus has no cure. There are several treatment options for patients, but there is still a lot of headway that needs to be made. There are three different types of medications for lupus: antimalarial drugs, corticosteroids, and biologics. Antimalarial drugs are the most common drug used for patients. They are also recommended for all lupus patients. This drug helps treat mouth and nose sores, arthritis, fatigue, rashes, and more.

Secondly, corticosteroids are another way lupus patients can find comfort. These medications are often paired with immune suppressants for patients with life-threatening issues related to lupus. Finally, biologics are the most recent treatment option for lupus patients. The medication was approved in 2011 for adults and then in 2019 for children.

Unfortunately, these treatment options are not always enough. Lupus can be a fatal disease, which is why it is important to find alternative treatment options. The medications listed above only help reduce symptoms and issues related to lupus. The SLE-BRAVE research study will help pave the way to a better treatment option.


The SLE-BRAVE study will last approximately 62 weeks or 14 months. The purpose of the research study is to test if Baricitinib, an investigational drug, and lupus therapy are effective lupus treatment options. Patients with lupus may qualify for this research study. It will help current, and future patients tackle the hardships lupus brings.

Eligible participants will take the medication orally every day for one year. There will be two groups: one group with the real drug and another group with a placebo. You, nor the doctor will know what form of the drug you will have. From there, patients will receive frequent check-ups with their study doctor. Visits will consist of weight, heart rate, blood pressure, and body temperature checks. It is our job to see how you are responding to the drug.

Participants will also be asked to journal their experience in a diary and fill out a questionnaire. Once the study is over, participants may have a chance to participate in the longer form of the study. More than 25 different countries are taking part in this study. Within those 25 countries, 340 clinical sites are participating.

Do you qualify?

Just because you have lupus does not mean you automatically qualify for this study. Visit the SLE-BRAVE website to fill out the questionnaire or view the requirements below.

Patients will need to meet the following requirements.

  • Must be at least 18 years
  • Willing and able to give consent for the study
  • Capable of visiting a study doctor
  • Currently has lupus and taking medication to treat the disease

You may fit all of these eligibility requirements, but some criteria may make you ineligible.

You cannot participate in this study if you fit any of the following.

  • Your lupus case affects your kidneys or nervous system
  • You have been treated for another autoimmune condition in the past 12 weeks
  • Currently have or have had another serious medical condition
  • Currently have or have had a serious infection
  • You have taken certain medications to treat your lupus in the past 12 months

If you are unsure if you qualify for the SLE-BRAVE research study, get in touch with Advanced Rheumatology of Houston today. Dr. Brionez can help you determine if you are eligible for this study. Give the clinic a call at (281) 766-7886. Take part in a research study that could help those with lupus.

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